Ngokusetyenziswa ngokubanzi kwe-fluoroquinolones, ukuxhathisa kwebhaktheriya kunye nokuchasana okungalunganga kuye kwenzeka enye emva kwenye.I-fluoroquinolones esandula ukuthengiswa njenge-temafloxacin yayekwa kuphela kwiiveki ezili-15 emva kokuba yaziswa e-UK ngo-1992 ngenxa yeziphumo ezibi ezifana nokwaliwa, ukopha, kunye nokusilela kwezintso.Ke ngoko, ayisikuko ukuba i-solubility ephezulu yamafutha kunye nexesha elide lesiqingatha sobomi, ngcono, kwaye i-pharmacokinetics kunye neenzuzo zeklinikhi kunye nokungalunganga kufuneka kuqwalaselwe ngokubanzi.